1: Lu H, Song J, Jia XB, Feng L. Antihepatoma Activity of the Acid and Neutral
Components from Ganoderma lucidum. Phytother Res. 2012 Jan 25. doi:
10.1002/ptr.3711. [Epub ahead of print] PubMed PMID: 22275242.


2: Li P, Deng YP, Wei XX, Xu JH. Triterpenoids from Ganoderma lucidum and their
cytotoxic activities. Nat Prod Res. 2012 Jan 20. [Epub ahead of print] PubMed
PMID: 22263904.


3: Zhao H, Zhang Q, Zhao L, Huang X, Wang J, Kang X. Spore Powder of Ganoderma
lucidum Improves Cancer-Related Fatigue in Breast Cancer Patients Undergoing
Endocrine Therapy: A Pilot Clinical Trial. Evid Based Complement Alternat Med.
2012;2012:809614. Epub 2011 Dec 10. PubMed PMID: 22203880; PubMed Central PMCID: 
PMC3236089.


4: Jang KJ, Son IS, Shin DY, Yoon HM, Choi YH. Anti-invasive activity of ethanol 
extracts of Ganoderma lucidum through tightening of tight junctions and
inhibition of matrix metalloproteinase activities in human gastric carcinoma
cells. J Acupunct Meridian Stud. 2011 Dec;4(4):225-35. doi:
10.1016/j.jams.2011.09.013. Epub 2011 Oct 20. PubMed PMID: 22196505.


5: Liang C, Li H, Zhou H, Zhang S, Liu Z, Zhou Q, Sun F. Recombinant Lz-8 from
Ganoderma lucidum induces endoplasmic reticulum stress-mediated autophagic cell
death in SGC-7901 human gastric cancer cells. Oncol Rep. 2012 Apr;27(4):1079-89. 
doi: 10.3892/or.2011.1593. Epub 2011 Dec 14. PubMed PMID: 22179718.


6: Wu GS, Lu JJ, Guo JJ, Li YB, Tan W, Dang YY, Zhong ZF, Xu ZT, Chen XP, Wang
YT. Ganoderic acid DM, a natural triterpenoid, induces DNA damage, G1 cell cycle 
arrest and apoptosis in human breast cancer cells. Fitoterapia. 2012
Mar;83(2):408-14. Epub 2011 Dec 9. PubMed PMID: 22178684.


7: Wang JH, Zhou YJ, Zhang M, Kan L, He P. Active lipids of Ganoderma lucidum
spores-induced apoptosis in human leukemia THP-1 cells via MAPK and PI3K
pathways. J Ethnopharmacol. 2012 Jan 31;139(2):582-9. Epub 2011 Dec 6. PubMed
PMID: 22172327.


8: Sudheesh NP, Ajith TA, Mathew J, Nima N, Janardhanan KK. Ganoderma lucidum
protects liver mitochondrial oxidative stress and improves the activity of
electron transport chain in carbon tetrachloride intoxicated rats. Hepatol Res.
2012 Feb;42(2):181-91. doi: 10.1111/j.1872-034X.2011.00906.x. Epub 2011 Nov 3.
PubMed PMID: 22050471.


9: Kennedy EM, P'Pool SJ, Jiang J, Sliva D, Minto RE. Semisynthesis and
biological evaluation of ganodermanontriol and its stereoisomeric triols. J Nat
Prod. 2011 Nov 28;74(11):2332-7. Epub 2011 Nov 1. PubMed PMID: 22044278.


10: Jiang J, Jedinak A, Sliva D. Ganodermanontriol (GDNT) exerts its effect on
growth and invasiveness of breast cancer cells through the down-regulation of
CDC20 and uPA. Biochem Biophys Res Commun. 2011 Nov 18;415(2):325-9. Epub 2011
Oct 18. PubMed PMID: 22033405.


11: Smina TP, Mathew J, Janardhanan KK, Devasagayam TP. Antioxidant activity and 
toxicity profile of total triterpenes isolated from Ganoderma lucidum (Fr.) P.
Karst occurring in South India. Environ Toxicol Pharmacol. 2011 Nov;32(3):438-46.
Epub 2011 Aug 30. PubMed PMID: 22004964.


12: Wu CT, Lin TY, Hsu HY, Sheu F, Ho CM, Chen EI. Ling Zhi-8 mediates
p53-dependent growth arrest of lung cancer cells proliferation via the ribosomal 
protein S7-MDM2-p53 pathway. Carcinogenesis. 2011 Dec;32(12):1890-6. Epub 2011
Oct 7. PubMed PMID: 21983128.


13: Smina TP, De S, Devasagayam TP, Adhikari S, Janardhanan KK. Ganoderma lucidum
total triterpenes prevent radiation-induced DNA damage and apoptosis in splenic
lymphocytes in vitro. Mutat Res. 2011 Dec 24;726(2):188-94. Epub 2011 Sep 16.
PubMed PMID: 21944902.


14: Thyagarajan-Sahu A, Lane B, Sliva D. ReishiMax, mushroom based dietary
supplement, inhibits adipocyte differentiation, stimulates glucose uptake and
activates AMPK. BMC Complement Altern Med. 2011 Sep 19;11:74. PubMed PMID:
21929808; PubMed Central PMCID: PMC3224355.


15: Martínez-Montemayor MM, Acevedo RR, Otero-Franqui E, Cubano LA,
Dharmawardhane SF. Ganoderma lucidum (Reishi) inhibits cancer cell growth and
expression of key molecules in inflammatory breast cancer. Nutr Cancer. 2011
Oct;63(7):1085-94. Epub 2011 Sep 2. PubMed PMID: 21888505; PubMed Central PMCID: 
PMC3201987.


16: Hsieh TC, Wu JM. Suppression of proliferation and oxidative stress by
extracts of Ganoderma lucidum in the ovarian cancer cell line OVCAR-3. Int J Mol 
Med. 2011 Dec;28(6):1065-9. doi: 10.3892/ijmm.2011.788. Epub 2011 Sep 1. PubMed
PMID: 21887458.


17: Sudheesh NP, Ajith TA, Janardhanan KK. Ganoderma lucidum ameliorate
mitochondrial damage in isoproterenol-induced myocardial infarction in rats by
enhancing the activities of TCA cycle enzymes and respiratory chain complexes.
Int J Cardiol. 2011 Aug 22. [Epub ahead of print] PubMed PMID: 21864918.


18: Haniadka R, Popouri S, Palatty PL, Arora R, Baliga MS. Medicinal Plants as
Antiemetics in the Treatment of Cancer: A Review. Integr Cancer Ther. 2011 Aug 5.
[Epub ahead of print] PubMed PMID: 21821652.


19: Yuen JW, Gohel MD, Ng CF. The differential immunological activities of
Ganoderma lucidum on human pre-cancerous uroepithelial cells. J Ethnopharmacol.
2011 Jun 1;135(3):711-8. Epub 2011 Apr 9. PubMed PMID: 21501679.


20: Lin CC, Yu YL, Shih CC, Liu KJ, Ou KL, Hong LZ, Chen JD, Chu CL. A novel
adjuvant Ling Zhi-8 enhances the efficacy of DNA cancer vaccine by activating
dendritic cells. Cancer Immunol Immunother. 2011 Jul;60(7):1019-27. Epub 2011 Apr
17. PubMed PMID: 21499904.


21: Sun LX, Lin ZB, Duan XS, Lu J, Ge ZH, Li XJ, Li M, Xing EH, Jia J, Lan TF, Li
WD. Ganoderma lucidum polysaccharides antagonize the suppression on lymphocytes
induced by culture supernatants of B16F10 melanoma cells. J Pharm Pharmacol. 2011
May;63(5):725-35. doi: 10.1111/j.2042-7158.2011.01266.x. PubMed PMID: 21492175.


22: Jiang J, Eliaz I, Sliva D. Suppression of growth and invasive behavior of
human prostate cancer cells by ProstaCaid™: mechanism of activity. Int J Oncol.
2011 Jun;38(6):1675-82. doi: 10.3892/ijo.2011.996. Epub 2011 Apr 4. PubMed PMID: 
21468543.


23: Zhao S, Ye G, Fu G, Cheng JX, Yang BB, Peng C. Ganoderma lucidum exerts
anti-tumor effects on ovarian cancer cells and enhances their sensitivity to
cisplatin. Int J Oncol. 2011 May;38(5):1319-27. doi: 10.3892/ijo.2011.965. Epub
2011 Mar 8. PubMed PMID: 21399867.


24: Chen NH, Zhong JJ. p53 is important for the anti-invasion of ganoderic acid T
in human carcinoma cells. Phytomedicine. 2011 Jun 15;18(8-9):719-25. Epub 2011
Feb 25. PubMed PMID: 21353507.


25: Chen Y, Lu H, Song S, Jia X. [Preparation of Ganoderma lucidum
polysaccharides and triterpenes microemulsion and its anticancer effect in mice
with transplant Heps tumors]. Zhongguo Zhong Yao Za Zhi. 2010 Oct;35(20):2679-83.
Chinese. PubMed PMID: 21246817.


26: Gordan JD, Chay WY, Kelley RK, Ko AH, Choo SP, Venook AP. "And what other
medications are you taking?". J Clin Oncol. 2011 Apr 10;29(11):e288-91. Epub 2011
Jan 18. PubMed PMID: 21245436.


27: Jedinak A, Thyagarajan-Sahu A, Jiang J, Sliva D. Ganodermanontriol, a
lanostanoid triterpene from Ganoderma lucidum, suppresses growth of colon cancer 
cells through ß-catenin signaling. Int J Oncol. 2011 Mar;38(3):761-7. doi:
10.3892/ijo.2011.898. Epub 2011 Jan 11. PubMed PMID: 21225227.


28: Xu Z, Chen X, Zhong Z, Chen L, Wang Y. Ganoderma lucidum polysaccharides:
immunomodulation and potential anti-tumor activities. Am J Chin Med.
2011;39(1):15-27. Review. PubMed PMID: 21213395.


29: Olaku O, White JD. Herbal therapy use by cancer patients: a literature review
on case reports. Eur J Cancer. 2011 Mar;47(4):508-14. Epub 2010 Dec 23. Review.
PubMed PMID: 21185719; PubMed Central PMCID: PMC3057114.


30: Shang D, Li Y, Wang C, Wang X, Yu Z, Fu X. A novel polysaccharide from
Se-enriched Ganoderma lucidum induces apoptosis of human breast cancer cells.
Oncol Rep. 2011 Jan;25(1):267-72. PubMed PMID: 21109986.


31: Jiang J, Sliva D. Novel medicinal mushroom blend suppresses growth and
invasiveness of human breast cancer cells. Int J Oncol. 2010 Dec;37(6):1529-36.
PubMed PMID: 21042722.


32: Liu RM, Zhong JJ. Ganoderic acid Mf and S induce mitochondria mediated
apoptosis in human cervical carcinoma HeLa cells. Phytomedicine. 2011 Mar
15;18(5):349-55. Epub 2010 Oct 29. PubMed PMID: 21036023.


33: Sun LX, Lin ZB, Li XJ, Li M, Lu J, Duan XS, Ge ZH, Song YX, Xing EH, Li WD.
Promoting effects of Ganoderma lucidum polysaccharides on B16F10 cells to
activate lymphocytes. Basic Clin Pharmacol Toxicol. 2011 Mar;108(3):149-54. doi: 
10.1111/j.1742-7843.2010.00632.x. Epub 2010 Oct 22. PubMed PMID: 20964805.


34: Zhang J, Tang Q, Zhou C, Jia W, Da Silva L, Nguyen LD, Reutter W, Fan H.
GLIS, a bioactive proteoglycan fraction from Ganoderma lucidum, displays
anti-tumour activity by increasing both humoral and cellular immune response.
Life Sci. 2010 Nov 20;87(19-22):628-37. Epub 2010 Oct 1. PubMed PMID: 20888840.


35: Li N, Hu YL, He CX, Hu CJ, Zhou J, Tang GP, Gao JQ. Preparation,
characterisation and anti-tumour activity of Ganoderma lucidum polysaccharide
nanoparticles. J Pharm Pharmacol. 2010 Jan;62(1):139-44. PubMed PMID: 20723010.


36: Wang JL, Li YB, Liu RM, Zhong JJ. A new ganoderic acid from Ganoderma lucidum
mycelia. J Asian Nat Prod Res. 2010 Aug;12(8):727-30. PubMed PMID: 20706913.


37: Lin CY, Chen YH, Lin CY, Hsu HY, Wang SH, Liang CJ, Kuan II, Wu PJ, Pai PY,
Wu CC, Chen YL. Ganoderma lucidum polysaccharides attenuate endotoxin-induced
intercellular cell adhesion molecule-1 expression in cultured smooth muscle cells
and in the neointima in mice. J Agric Food Chem. 2010 Sep 8;58(17):9563-71.
PubMed PMID: 20687608.


38: Huang CY, Chen JY, Wu JE, Pu YS, Liu GY, Pan MH, Huang YT, Huang AM, Hwang
CC, Chung SJ, Hour TC. Ling-Zhi polysaccharides potentiate cytotoxic effects of
anticancer drugs against drug-resistant urothelial carcinoma cells. J Agric Food 
Chem. 2010 Aug 11;58(15):8798-805. PubMed PMID: 20681668.


39: Jang KJ, Han MH, Lee BH, Kim BW, Kim CH, Yoon HM, Choi YH. Induction of
apoptosis by ethanol extracts of Ganoderma lucidum in human gastric carcinoma
cells. J Acupunct Meridian Stud. 2010 Mar;3(1):24-31. PubMed PMID: 20633512.


40: Shimojo Y, Kosaka K, Shirasawa T. Effect of Ganoderma lucidum extract on
adipocyte differentiation and adiponectin gene expression in the murine
pre-adipocyte cell line, 3T3-L1. Phytother Res. 2011 Feb;25(2):202-7. doi:
10.1002/ptr.3242. PubMed PMID: 20632304.


41: Cheng CR, Yue QX, Wu ZY, Song XY, Tao SJ, Wu XH, Xu PP, Liu X, Guan SH, Guo
DA. Cytotoxic triterpenoids from Ganoderma lucidum. Phytochemistry. 2010
Sep;71(13):1579-85. Epub 2010 Jul 6. PubMed PMID: 20615519.


42: Liu J, Shimizu K, Kondo R. The effects of ganoderma alcohols isolated from
Ganoderma lucidum on the androgen receptor binding and the growth of LNCaP cells.
Fitoterapia. 2010 Dec;81(8):1067-72. Epub 2010 Jul 23. PubMed PMID: 20603196.


43: Thyagarajan A, Jedinak A, Nguyen H, Terry C, Baldridge LA, Jiang J, Sliva D. 
Triterpenes from Ganoderma Lucidum induce autophagy in colon cancer through the
inhibition of p38 mitogen-activated kinase (p38 MAPK). Nutr Cancer.
2010;62(5):630-40. PubMed PMID: 20574924.


44: Calviño E, Pajuelo L, Casas JA, Manjón JL, Tejedor MC, Herráez A, Alonso MD, 
Diez JC. Cytotoxic action of Ganoderma lucidum on interleukin-3 dependent
lymphoma DA-1 cells: involvement of apoptosis proteins. Phytother Res. 2011
Jan;25(1):25-32. doi: 10.1002/ptr.3202. PubMed PMID: 20568239.


45: Price LA, Wenner CA, Sloper DT, Slaton JW, Novack JP. Role for toll-like
receptor 4 in TNF-alpha secretion by murine macrophages in response to
polysaccharide Krestin, a Trametes versicolor mushroom extract. Fitoterapia. 2010
Oct;81(7):914-9. Epub 2010 Jun 13. PubMed PMID: 20550956.


46: Oka S, Tanaka S, Yoshida S, Hiyama T, Ueno Y, Ito M, Kitadai Y, Yoshihara M, 
Chayama K. A water-soluble extract from culture medium of Ganoderma lucidum
mycelia suppresses the development of colorectal adenomas. Hiroshima J Med Sci.
2010 Mar;59(1):1-6. PubMed PMID: 20518254.


47: Weng CJ, Yen GC. The in vitro and in vivo experimental evidences disclose the
chemopreventive effects of Ganoderma lucidum on cancer invasion and metastasis.
Clin Exp Metastasis. 2010 May;27(5):361-9. Epub 2010 May 12. Review. PubMed PMID:
20461449.


48: Yoshimura K, Kamoto T, Ogawa O, Matsui S, Tsuchiya N, Tada H, Murata K,
Yoshimura K, Habuchi T, Fukushima M. Medical mushrooms used for biochemical
failure after radical treatment for prostate cancer: an open-label study. Int J
Urol. 2010 Jun;17(6):548-54. Epub 2010 Apr 19. PubMed PMID: 20412340.


49: Chen NH, Liu JW, Zhong JJ. Ganoderic acid T inhibits tumor invasion in vitro 
and in vivo through inhibition of MMP expression. Pharmacol Rep. 2010
Jan-Feb;62(1):150-63. PubMed PMID: 20360625.


50: Ferretti R, Palumbo V, Di Savino A, Velasco S, Sbroggiò M, Sportoletti P,
Micale L, Turco E, Silengo L, Palumbo G, Hirsch E, Teruya-Feldstein J, Bonaccorsi
S, Pandolfi PP, Gatti M, Tarone G, Brancaccio M. Morgana/chp-1, a ROCK inhibitor 
involved in centrosome duplication and tumorigenesis. Dev Cell. 2010 Mar
16;18(3):486-95. PubMed PMID: 20230755.


51: Yue QX, Song XY, Ma C, Feng LX, Guan SH, Wu WY, Yang M, Jiang BH, Liu X, Cui 
YJ, Guo DA. Effects of triterpenes from Ganoderma lucidum on protein expression
profile of HeLa cells. Phytomedicine. 2010 Jul;17(8-9):606-13. Epub 2010 Jan 25. 
PubMed PMID: 20092987.


52: Sudheesh NP, Ajith TA, Ramnath V, Janardhanan KK. Therapeutic potential of
Ganoderma lucidum (Fr.) P. Karst. against the declined antioxidant status in the 
mitochondria of post-mitotic tissues of aged mice. Clin Nutr. 2010
Jun;29(3):406-12. Epub 2009 Dec 30. PubMed PMID: 20044182.


53: Calviño E, Manjón JL, Sancho P, Tejedor MC, Herráez A, Diez JC. Ganoderma
lucidum induced apoptosis in NB4 human leukemia cells: involvement of Akt and
Erk. J Ethnopharmacol. 2010 Mar 2;128(1):71-8. Epub 2009 Dec 29. PubMed PMID:
20036724.


54: Sze DM, Chan GC. Supplements for immune enhancement in hematologic
malignancies. Hematology Am Soc Hematol Educ Program. 2009:313-9. Review. PubMed 
PMID: 20008216.


55: Chang YH, Yang JS, Yang JL, Wu CL, Chang SJ, Lu KW, Lin JJ, Hsia TC, Lin YT, 
Ho CC, Wood WG, Chung JG. Ganoderma lucidum extracts inhibited leukemia WEHI-3
cells in BALB/c mice and promoted an immune response in vivo. Biosci Biotechnol
Biochem. 2009 Dec;73(12):2589-94. Epub 2009 Dec 7. PubMed PMID: 19966494.


56: Wang J, Zhang L, Yu Y, Cheung PC. Enhancement of antitumor activities in
sulfated and carboxymethylated polysaccharides of Ganoderma lucidum. J Agric Food
Chem. 2009 Nov 25;57(22):10565-72. PubMed PMID: 19863048.


57: Evans S, Dizeyi N, Abrahamsson PA, Persson J. The effect of a novel botanical
agent TBS-101 on invasive prostate cancer in animal models. Anticancer Res. 2009 
Oct;29(10):3917-24. PubMed PMID: 19846929.


58: Harhaji Trajković LM, Mijatović SA, Maksimović-Ivanić DD, Stojanović ID,
Momcilović MB, Tufegdzić SJ, Maksimović VM, Marjanović ZS, Stosić-Grujicić SD.
Anticancer properties of Ganoderma lucidum methanol extracts in vitro and in
vivo. Nutr Cancer. 2009;61(5):696-707. PubMed PMID: 19838944.


59: Chang YH, Yang JS, Yang JL, Wu CL, Chang SJ, Lu KW, Kuo CL, Hsia TC, Chung
JG. Gandoderma lucidum extract promotes immune responses in normal BALB/c mice In
vivo. In Vivo. 2009 Sep-Oct;23(5):755-9. PubMed PMID: 19779111.


60: Liu G, Ding C, Zhang K, Wang X. [Effects of medicinal insect Catharsius
molossus on submerged fermentation and in vivo anti-hepatoma activity of
Ganoderma lucidum]. Sheng Wu Gong Cheng Xue Bao. 2009 Jun;25(6):880-6. Chinese.
PubMed PMID: 19777816.


61: Cassileth B. Complementary therapies, herbs, and other OTC agents: Reishi
mushroom. Oncology (Williston Park). 2009 Jul;23(8):728. PubMed PMID: 19711590.


62: Hsu JW, Huang HC, Chen ST, Wong CH, Juan HF. Ganoderma lucidum
Polysaccharides Induce Macrophage-like Differentiation in Human Leukemia THP-1
Cells via Caspase and p53 Activation. Evid Based Complement Alternat Med. 2009
Aug 20. [Epub ahead of print] PubMed PMID: 19696196; PubMed Central PMCID:
PMC3135330.


63: Shang D, Zhang J, Wen L, Li Y, Cui Q. Preparation, characterization, and
antiproliferative activities of the Se-containing polysaccharide SeGLP-2B-1 from 
Se-enriched Ganoderma lucidum. J Agric Food Chem. 2009 Sep 9;57(17):7737-42.
PubMed PMID: 19678686.


64: Dudhgaonkar S, Thyagarajan A, Sliva D. Suppression of the inflammatory
response by triterpenes isolated from the mushroom Ganoderma lucidum. Int
Immunopharmacol. 2009 Oct;9(11):1272-80. Epub 2009 Aug 3. PubMed PMID: 19651243.


65: Ahmadi K, Riazipour M. Ganoderma lucidum induces the expression of CD40/CD86 
on peripheral blood monocytes. Iran J Immunol. 2009 Jun;6(2):87-91. PubMed PMID: 
19561377.


66: Guo L, Xie J, Ruan Y, Zhou L, Zhu H, Yun X, Jiang Y, Lü L, Chen K, Min Z, Wen
Y, Gu J. Characterization and immunostimulatory activity of a polysaccharide from
the spores of Ganoderma lucidum. Int Immunopharmacol. 2009 Sep;9(10):1175-82.
Epub 2009 Jun 21. PubMed PMID: 19540939.


67: Zhou GQ, Zhao HY, Lu C. [Effect of Ganoderma lucidum polysaccharides on
intestinal mucosal immune system in H22 liver cancer bearing mice]. Zhongguo
Zhong Xi Yi Jie He Za Zhi. 2009 Apr;29(4):335-9. Chinese. PubMed PMID: 19526760.


68: Chen YK, Kuo YH, Chiang BH, Lo JM, Sheen LY. Cytotoxic activities of
9,11-dehydroergosterol peroxide and ergosterol peroxide from the fermentation
mycelia of ganoderma lucidum cultivated in the medium containing leguminous
plants on Hep 3B cells. J Agric Food Chem. 2009 Jul 8;57(13):5713-9. PubMed PMID:
19492810.


69: Weng CJ, Chau CF, Yen GC, Liao JW, Chen DH, Chen KD. Inhibitory effects of
ganoderma lucidum on tumorigenesis and metastasis of human hepatoma cells in
cells and animal models. J Agric Food Chem. 2009 Jun 10;57(11):5049-57. PubMed
PMID: 19422227.


70: Liu YW, Gao JL, Guan J, Qian ZM, Feng K, Li SP. Evaluation of
antiproliferative activities and action mechanisms of extracts from two species
of Ganoderma on tumor cell lines. J Agric Food Chem. 2009 Apr 22;57(8):3087-93.
PubMed PMID: 19368349.


71: Liu J, Shiono J, Shimizu K, Kukita A, Kukita T, Kondo R. Ganoderic acid DM:
anti-androgenic osteoclastogenesis inhibitor. Bioorg Med Chem Lett. 2009 Apr
15;19(8):2154-7. Epub 2009 Mar 4. PubMed PMID: 19289282.


72: Liu J, Tamura S, Kurashiki K, Shimizu K, Noda K, Konishi F, Kumamoto S, Kondo
R. Anti-androgen effects of extracts and compounds from Ganoderma lucidum. Chem
Biodivers. 2009 Feb;6(2):231-43. PubMed PMID: 19235153.


73: Li L, Li T, Wang XJ, Xu JP, Wang SG. [Effects of Ganoderma lucidum spores on 
HepG2 cells proliferation and growth cycle]. Zhong Yao Cai. 2008
Oct;31(10):1514-8. Chinese. PubMed PMID: 19230404.


74: Sadava D, Still DW, Mudry RR, Kane SE. Effect of Ganoderma on drug-sensitive 
and multidrug-resistant small-cell lung carcinoma cells. Cancer Lett. 2009 May
18;277(2):182-9. Epub 2009 Feb 1. PubMed PMID: 19188016.


75: Xue Q, Ding Y, Shang C, Jiang C, Zhao M. Functional expression of LZ-8, a
fungal immunomodulatory protein from Ganoderma lucidium in Pichia pastoris. J Gen
Appl Microbiol. 2008 Dec;54(6):393-8. PubMed PMID: 19164882.


76: Zhuang SR, Chen SL, Tsai JH, Huang CC, Wu TC, Liu WS, Tseng HC, Lee HS, Huang
MC, Shane GT, Yang CH, Shen YC, Yan YY, Wang CK. Effect of citronellol and the
Chinese medical herb complex on cellular immunity of cancer patients receiving
chemotherapy/radiotherapy. Phytother Res. 2009 Jun;23(6):785-90. PubMed PMID:
19145638.


77: Sudheesh NP, Ajith TA, Janardhanan KK. Ganoderma lucidum (Fr.) P. Karst
enhances activities of heart mitochondrial enzymes and respiratory chain
complexes in the aged rat. Biogerontology. 2009 Oct;10(5):627-36. Epub 2009 Jan
4. PubMed PMID: 19123066.


78: Mahajna J, Dotan N, Zaidman BZ, Petrova RD, Wasser SP. Pharmacological values
of medicinal mushrooms for prostate cancer therapy: the case of Ganoderma
lucidum. Nutr Cancer. 2009;61(1):16-26. Review. PubMed PMID: 19116872.


79: Driscoll M, Hansen R, Ding C, Cramer DE, Yan J. Therapeutic potential of
various beta-glucan sources in conjunction with anti-tumor monoclonal antibody in
cancer therapy. Cancer Biol Ther. 2009 Feb;8(3):218-25. Epub 2009 Feb 3. PubMed
PMID: 19106638.


80: Hsu SC, Ou CC, Li JW, Chuang TC, Kuo HP, Liu JY, Chen CS, Lin SC, Su CH, Kao 
MC. Ganoderma tsugae extracts inhibit colorectal cancer cell growth via G(2)/M
cell cycle arrest. J Ethnopharmacol. 2008 Dec 8;120(3):394-401. Epub 2008 Oct 2. 
PubMed PMID: 18951965.


81: Chen NH, Liu JW, Zhong JJ. Ganoderic acid Me inhibits tumor invasion through 
down-regulating matrix metalloproteinases 2/9 gene expression. J Pharmacol Sci.
2008 Oct;108(2):212-6. PubMed PMID: 18946196.


82: Pinweha S, Wanikiat P, Sanvarinda Y, Supavilai P. The signaling cascades of
Ganoderma lucidum extracts in stimulating non-amyloidogenic protein secretion in 
human neuroblastoma SH-SY5Y cell lines. Neurosci Lett. 2008 Dec 19;448(1):62-6.
Epub 2008 Oct 14. PubMed PMID: 18938219.


83: Fukuzawa M, Yamaguchi R, Hide I, Chen Z, Hirai Y, Sugimoto A, Yasuhara T,
Nakata Y. Possible involvement of long chain fatty acids in the spores of
Ganoderma lucidum (Reishi Houshi) to its anti-tumor activity. Biol Pharm Bull.
2008 Oct;31(10):1933-7. PubMed PMID: 18827358.


84: Guan SH, Xia JM, Yang M, Wang XM, Liu X, Guo DA. Cytotoxic lanostanoid
triterpenes from Ganoderma lucidum. J Asian Nat Prod Res. 2008
Jul-Aug;10(7-8):705-10. PubMed PMID: 18696320.


85: Li YB, Wang R, Wu HL, Li YH, Zhong LJ, Yu HM, Li XJ. Serum amyloid A mediates
the inhibitory effect of Ganoderma lucidum polysaccharides on tumor cell adhesion
to endothelial cells. Oncol Rep. 2008 Sep;20(3):549-56. PubMed PMID: 18695905.


86: Chan WK, Cheung CC, Law HK, Lau YL, Chan GC. Ganoderma lucidum
polysaccharides can induce human monocytic leukemia cells into dendritic cells
with immuno-stimulatory function. J Hematol Oncol. 2008 Jul 21;1:9. PubMed PMID: 
18644156; PubMed Central PMCID: PMC2517069.


87: Gill SK, Rieder MJ. Toxicity of a traditional Chinese medicine, Ganoderma
lucidum, in children with cancer. Can J Clin Pharmacol. 2008
Summer;15(2):e275-85. Epub 2008 Jul 4. PubMed PMID: 18603664.


88: Pillai TG, Nair CK, Janardhanan KK. Polysaccharides isolated from Ganoderma
lucidum occurring in Southern parts of India, protects radiation induced damages 
both in vitro and in vivo. Environ Toxicol Pharmacol. 2008 Jul;26(1):80-5. Epub
2008 Feb 14. PubMed PMID: 21783892.


89: Yue GG, Fung KP, Leung PC, Lau CB. Comparative studies on the
immunomodulatory and antitumor activities of the different parts of fruiting body
of Ganoderma lucidum and Ganoderma spores. Phytother Res. 2008
Oct;22(10):1282-91. PubMed PMID: 18570198.


90: Yuen JW, Gohel MD. The dual roles of Ganoderma antioxidants on urothelial
cell DNA under carcinogenic attack. J Ethnopharmacol. 2008 Jul 23;118(2):324-30. 
Epub 2008 May 8. PubMed PMID: 18550308.


91: Nonaka Y, Ishibashi H, Nakai M, Shibata H, Kiso Y, Abe S. Effects of the
antlered form of Ganoderma lucidum on tumor growth and metastasis in
cyclophosphamide-treated mice. Biosci Biotechnol Biochem. 2008
Jun;72(6):1399-408. Epub 2008 Jun 7. PubMed PMID: 18540114.


92: Yuen JW, Gohel MD, Au DW. Telomerase-associated apoptotic events by mushroom 
ganoderma lucidum on premalignant human urothelial cells. Nutr Cancer.
2008;60(1):109-19. PubMed PMID: 18444142.


93: Jiang J, Grieb B, Thyagarajan A, Sliva D. Ganoderic acids suppress growth and
invasive behavior of breast cancer cells by modulating AP-1 and NF-kappaB
signaling. Int J Mol Med. 2008 May;21(5):577-84. PubMed PMID: 18425349.


94: Yue QX, Xie FB, Guan SH, Ma C, Yang M, Jiang BH, Liu X, Guo DA. Interaction
of Ganoderma triterpenes with doxorubicin and proteomic characterization of the
possible molecular targets of Ganoderma triterpenes. Cancer Sci. 2008
Jul;99(7):1461-70. Epub 2008 Apr 16. PubMed PMID: 18422750.


95: Li L, Lei LS, Yu CL. [Changes of serum interferon-gamma levels in mice
bearing S-180 tumor and the interventional effect of immunomodulators]. Nan Fang 
Yi Ke Da Xue Xue Bao. 2008 Jan;28(1):65-8. Chinese. PubMed PMID: 18227030.


96: Yue QX, Cao ZW, Guan SH, Liu XH, Tao L, Wu WY, Li YX, Yang PY, Liu X, Guo DA.
Proteomics characterization of the cytotoxicity mechanism of ganoderic acid D and
computer-automated estimation of the possible drug target network. Mol Cell
Proteomics. 2008 May;7(5):949-61. Epub 2007 Dec 31. PubMed PMID: 18166740.


97: Weng CJ, Chau CF, Hsieh YS, Yang SF, Yen GC. Lucidenic acid inhibits
PMA-induced invasion of human hepatoma cells through inactivating MAPK/ERK signal
transduction pathway and reducing binding activities of NF-kappaB and AP-1.
Carcinogenesis. 2008 Jan;29(1):147-56. Epub 2007 Nov 16. PubMed PMID: 18024477.


98: Cheng KC, Huang HC, Chen JH, Hsu JW, Cheng HC, Ou CH, Yang WB, Chen ST, Wong 
CH, Juan HF. Ganoderma lucidum polysaccharides in human monocytic leukemia cells:
from gene expression to network construction. BMC Genomics. 2007 Nov 9;8:411.
PubMed PMID: 17996095; PubMed Central PMCID: PMC2211495.


99: Pang X, Chen Z, Gao X, Liu W, Slavin M, Yao W, Yu LL. Potential of a novel
polysaccharide preparation (GLPP) from Anhui-grown Ganoderma lucidum in tumor
treatment and immunostimulation. J Food Sci. 2007 Aug;72(6):S435-42. PubMed PMID:
17995702.


100: Weng CJ, Chau CF, Chen KD, Chen DH, Yen GC. The anti-invasive effect of
lucidenic acids isolated from a new Ganoderma lucidum strain. Mol Nutr Food Res. 
2007 Dec;51(12):1472-7. PubMed PMID: 17979098.


101: Zaidman BZ, Wasser SP, Nevo E, Mahajna J. Androgen receptor-dependent and
-independent mechanisms mediate Ganoderma lucidum activities in LNCaP prostate
cancer cells. Int J Oncol. 2007 Oct;31(4):959-67. PubMed PMID: 17786330.


102: Nakajima Y, Sato Y, Konishi T. Antioxidant small phenolic ingredients in
Inonotus obliquus (persoon) Pilat (Chaga). Chem Pharm Bull (Tokyo). 2007
Aug;55(8):1222-6. PubMed PMID: 17666849.


103: Li JJ, Lei LS, Yu CL, Zhu ZG, Zhang Q, Wu SG. [Effect of Ganoderma lucidum
polysaccharides on tumor cell nucleotide content and cell cycle in S180 ascitic
tumor-bearing mice]. Nan Fang Yi Ke Da Xue Xue Bao. 2007 Jul;27(7):1003-5.
Chinese. PubMed PMID: 17666337.


104: Chan WK, Law HK, Lin ZB, Lau YL, Chan GC. Response of human dendritic cells 
to different immunomodulatory polysaccharides derived from mushroom and barley.
Int Immunol. 2007 Jul;19(7):891-9. Epub 2007 Jul 2. PubMed PMID: 17606977.


105: Ji Z, Tang Q, Zhang J, Yang Y, Jia W, Pan Y. Immunomodulation of RAW264.7
macrophages by GLIS, a proteopolysaccharide from Ganoderma lucidum. J
Ethnopharmacol. 2007 Jul 25;112(3):445-50. Epub 2007 Apr 8. PubMed PMID:
17524580.


106: Liu J, Shimizu K, Konishi F, Kumamoto S, Kondo R. The anti-androgen effect
of ganoderol B isolated from the fruiting body of Ganoderma lucidum. Bioorg Med
Chem. 2007 Jul 15;15(14):4966-72. Epub 2007 Apr 25. PubMed PMID: 17499997.


107: Cheuk W, Chan JK, Nuovo G, Chan MK, Fok M. Regression of gastric large
B-Cell lymphoma accompanied by a florid lymphoma-like T-cell reaction:
immunomodulatory effect of Ganoderma lucidum (Lingzhi)? Int J Surg Pathol. 2007
Apr;15(2):180-6. PubMed PMID: 17478779.


108: Wang G, Zhao J, Liu J, Huang Y, Zhong JJ, Tang W. Enhancement of IL-2 and
IFN-gamma expression and NK cells activity involved in the anti-tumor effect of
ganoderic acid Me in vivo. Int Immunopharmacol. 2007 Jun;7(6):864-70. Epub 2007
Mar 13. PubMed PMID: 17466920.


109: Zaidman BZ, Wasser SP, Nevo E, Mahajna J. Coprinus comatus and Ganoderma
lucidum interfere with androgen receptor function in LNCaP prostate cancer cells.
Mol Biol Rep. 2008 Jun;35(2):107-17. Epub 2007 Mar 13. PubMed PMID: 17431821.


110: Wanachiwanawin D, Piankijagum A, Chaiprasert A, Lertlaituan P,
Tungtrongchitr A, Chinabutr P. Ganoderma lucidum: a cause of pseudoparasitosis.
Southeast Asian J Trop Med Public Health. 2006 Nov;37(6):1099-102. PubMed PMID:
17333761.


111: Thyagarajan A, Zhu J, Sliva D. Combined effect of green tea and Ganoderma
lucidum on invasive behavior of breast cancer cells. Int J Oncol. 2007
Apr;30(4):963-9. PubMed PMID: 17332936.


112: Zhu XL, Chen AF, Lin ZB. Ganoderma lucidum polysaccharides enhance the
function of immunological effector cells in immunosuppressed mice. J
Ethnopharmacol. 2007 May 4;111(2):219-26. Epub 2006 Nov 21. PubMed PMID:
17182202.


113: Wang DH, Weng XC. [Antitumor activity of extracts of Ganoderma lucidum and
their protective effects on damaged HL-7702 cells induced by radiotherapy and
chemotherapy]. Zhongguo Zhong Yao Za Zhi. 2006 Oct;31(19):1618-22. Chinese.
PubMed PMID: 17165589.


114: Chui CH, Wong RS, Cheng GY, Lau FY, Kok SH, Cheng CH, Cheung F, Tang WK, Teo
IT, Chan AS, Tang JC. Antiproliferative ability of a combination regimen of
crocodile egg extract, wild radix ginseng and natural Ganoderma lucidum on acute 
myelogenous leukemia. Oncol Rep. 2006 Dec;16(6):1313-6. PubMed PMID: 17089055.


115: Kashimoto N, Hayama M, Kamiya K, Watanabe H. Inhibitory effect of a
water-soluble extract from the culture medium of Ganoderma lucidum (Rei-shi)
mycelia on the development of pulmonary adenocarcinoma induced by N-nitrosobis
(2-hydroxypropyl) amine in Wistar rats. Oncol Rep. 2006 Dec;16(6):1181-7. PubMed 
PMID: 17089035.


116: Yue GG, Fung KP, Tse GM, Leung PC, Lau CB. Comparative studies of various
ganoderma species and their different parts with regard to their antitumor and
immunomodulating activities in vitro. J Altern Complement Med. 2006
Oct;12(8):777-89. PubMed PMID: 17034284.


117: Tang W, Liu JW, Zhao WM, Wei DZ, Zhong JJ. Ganoderic acid T from Ganoderma
lucidum mycelia induces mitochondria mediated apoptosis in lung cancer cells.
Life Sci. 2006 Dec 23;80(3):205-11. Epub 2006 Sep 6. PubMed PMID: 17007887.


118: Thyagarajan A, Jiang J, Hopf A, Adamec J, Sliva D. Inhibition of oxidative
stress-induced invasiveness of cancer cells by Ganoderma lucidum is mediated
through the suppression of interleukin-8 secretion. Int J Mol Med. 2006
Oct;18(4):657-64. PubMed PMID: 16964420.


119: Nonaka Y, Shibata H, Nakai M, Kurihara H, Ishibashi H, Kiso Y, Tanaka T,
Yamaguchi H, Abe S. Anti-tumor activities of the antlered form of Ganoderma
lucidum in allogeneic and syngeneic tumor-bearing mice. Biosci Biotechnol
Biochem. 2006 Sep;70(9):2028-34. Epub 2006 Sep 7. PubMed PMID: 16960396.


120: Paterson RR. Ganoderma - a therapeutic fungal biofactory. Phytochemistry.
2006 Sep;67(18):1985-2001. Epub 2006 Aug 14. Review. PubMed PMID: 16905165.


121: Jiang J, Slivova V, Sliva D. Ganoderma lucidum inhibits proliferation of
human breast cancer cells by down-regulation of estrogen receptor and NF-kappaB
signaling. Int J Oncol. 2006 Sep;29(3):695-703. PubMed PMID: 16865287.


122: Lakshmi B, Ajith TA, Jose N, Janardhanan KK. Antimutagenic activity of
methanolic extract of Ganoderma lucidum and its effect on hepatic damage caused
by benzo[a]pyrene. J Ethnopharmacol. 2006 Sep 19;107(2):297-303. Epub 2006 Apr 6.
PubMed PMID: 16713154.


123: Xie JT, Wang CZ, Wicks S, Yin JJ, Kong J, Li J, Li YC, Yuan CS. Ganoderma
lucidum extract inhibits proliferation of SW 480 human colorectal cancer cells.
Exp Oncol. 2006 Mar;28(1):25-9. PubMed PMID: 16614703.


124: Kim KC, Kim JS, Son JK, Kim IG. Enhanced induction of mitochondrial damage
and apoptosis in human leukemia HL-60 cells by the Ganoderma lucidum and
Duchesnea chrysantha extracts. Cancer Lett. 2007 Feb 8;246(1-2):210-7. Epub 2006 
Mar 29. PubMed PMID: 16574319.


125: Sliva D. Ganoderma lucidum in cancer research. Leuk Res. 2006
Jul;30(7):767-8. Epub 2006 Feb 3. PubMed PMID: 16458355.


126: Chen X, Hu ZP, Yang XX, Huang M, Gao Y, Tang W, Chan SY, Dai X, Ye J, Ho PC,
Duan W, Yang HY, Zhu YZ, Zhou SF. Monitoring of immune responses to a herbal
immuno-modulator in patients with advanced colorectal cancer. Int
Immunopharmacol. 2006 Mar;6(3):499-508. Epub 2005 Sep 15. PubMed PMID: 16428086.


127: Müller CI, Kumagai T, O'Kelly J, Seeram NP, Heber D, Koeffler HP. Ganoderma 
lucidum causes apoptosis in leukemia, lymphoma and multiple myeloma cells. Leuk
Res. 2006 Jul;30(7):841-8. Epub 2006 Jan 19. PubMed PMID: 16423392.


128: Chan WK, Lam DT, Law HK, Wong WT, Koo MW, Lau AS, Lau YL, Chan GC. Ganoderma
lucidum mycelium and spore extracts as natural adjuvants for immunotherapy. J
Altern Complement Med. 2005 Dec;11(6):1047-57. PubMed PMID: 16398597.


129: Johnston N. Medicinal mushroom cuts off prostate cancer cells' blood supply.
Drug Discov Today. 2005 Dec;10(23-24):1584. PubMed PMID: 16376814.


130: Yuen JW, Gohel MD. Anticancer effects of Ganoderma lucidum: a review of
scientific evidence. Nutr Cancer. 2005;53(1):11-7. Review. PubMed PMID: 16351502.


131: Woo CW, Man RY, Siow YL, Choy PC, Wan EW, Lau CS, O K. Ganoderma lucidum
inhibits inducible nitric oxide synthase expression in macrophages. Mol Cell
Biochem. 2005 Jul;275(1-2):165-71. PubMed PMID: 16335796.


132: Nonaka Y, Ishibashi H, Nakai M, Shibata H, Kiso Y, Abe S. [Soothing effect
of Ganoderma lucidum antlered form on cyclophosphamide-induced adverse reaction].
Gan To Kagaku Ryoho. 2005 Oct;32(11):1586-8. Japanese. PubMed PMID: 16315878.


133: Cao QZ, Lin ZB. Ganoderma lucidum polysaccharides peptide inhibits the
growth of vascular endothelial cell and the induction of VEGF in human lung
cancer cell. Life Sci. 2006 Feb 23;78(13):1457-63. Epub 2005 Nov 2. PubMed PMID: 
16269156.


134: Chung WT, Lee SH, Kim JD, Park YS, Hwang B, Lee SY, Lee HY. Effect of
mycelial culture broth of Ganoderma lucidum on the growth characteristics of
human cell lines. J Biosci Bioeng. 2001;92(6):550-5. PubMed PMID: 16233144.


135: [Luminous quack doctor]. Praxis (Bern 1994). 2005 Sep 21;94(38):1497.
German. PubMed PMID: 16209366.


136: Gao Y, Tang W, Dai X, Gao H, Chen G, Ye J, Chan E, Koh HL, Li X, Zhou S.
Effects of water-soluble Ganoderma lucidum polysaccharides on the immune
functions of patients with advanced lung cancer. J Med Food. 2005
Summer;8(2):159-68. PubMed PMID: 16117607.


137: Yang HL. Ganoderic acid produced from submerged culture of Ganoderma lucidum
induces cell cycle arrest and cytotoxicity in human hepatoma cell line BEL7402.
Biotechnol Lett. 2005 Jun;27(12):835-8. PubMed PMID: 16086244.


138: Kwok Y, Ng KF, Li CC, Lam CC, Man RY. A prospective, randomized,
double-blind, placebo-controlled study of the platelet and global hemostatic
effects of Ganoderma lucidum (Ling-Zhi) in healthy volunteers. Anesth Analg. 2005
Aug;101(2):423-6, table of contents. PubMed PMID: 16037156.


139: Jiang Y, Wang H, Lü L, Tian GY. [Chemistry of polysaccharide Lzps-1 from
Ganoderma lucidum spore and anti-tumor activity of its total polysaccharides].
Yao Xue Xue Bao. 2005 Apr;40(4):347-50. Chinese. PubMed PMID: 16011264.


140: Yang HL, Chen GH, Li YQ. A quantum chemical and statistical study of
ganoderic acids with cytotoxicity against tumor cell. Eur J Med Chem. 2005
Oct;40(10):972-6. Epub 2005 Jul 11. PubMed PMID: 16006013.


141: Gao Y, Gao H, Chan E, Tang W, Xu A, Yang H, Huang M, Lan J, Li X, Duan W, Xu
C, Zhou S. Antitumor activity and underlying mechanisms of ganopoly, the refined 
polysaccharides extracted from Ganoderma lucidum, in mice. Immunol Invest.
2005;34(2):171-98. PubMed PMID: 15921158.


142: Tang W, Gao Y, Chen G, Gao H, Dai X, Ye J, Chan E, Huang M, Zhou S. A
randomized, double-blind and placebo-controlled study of a Ganoderma lucidum
polysaccharide extract in neurasthenia. J Med Food. 2005 Spring;8(1):53-8. PubMed
PMID: 15857210.


143: Kimura Y. New anticancer agents: in vitro and in vivo evaluation of the
antitumor and antimetastatic actions of various compounds isolated from medicinal
plants. In Vivo. 2005 Jan-Feb;19(1):37-60. Review. PubMed PMID: 15796155.


144: Stanley G, Harvey K, Slivova V, Jiang J, Sliva D. Ganoderma lucidum
suppresses angiogenesis through the inhibition of secretion of VEGF and TGF-beta1
from prostate cancer cells. Biochem Biophys Res Commun. 2005 Apr 29;330(1):46-52.
PubMed PMID: 15781230.


145: Gu YH, Belury MA. Selective induction of apoptosis in murine skin carcinoma 
cells (CH72) by an ethanol extract of Lentinula edodes. Cancer Lett. 2005 Mar
18;220(1):21-8. PubMed PMID: 15737684.


146: Boon H, Wong J. Botanical medicine and cancer: a review of the safety and
efficacy. Expert Opin Pharmacother. 2004 Dec;5(12):2485-501. Review. PubMed PMID:
15571467.


147: Zhang W, Zeng YS. [Progress in research on Ganoderma lucidium spore]. Zhong 
Xi Yi Jie He Xue Bao. 2004 Nov;2(6):463-5. Review. Chinese. PubMed PMID:
15539032.


148: Lu QY, Jin YS, Zhang Q, Zhang Z, Heber D, Go VL, Li FP, Rao JY. Ganoderma
lucidum extracts inhibit growth and induce actin polymerization in bladder cancer
cells in vitro. Cancer Lett. 2004 Dec 8;216(1):9-20. PubMed PMID: 15500944.


149: Jiang J, Slivova V, Harvey K, Valachovicova T, Sliva D. Ganoderma lucidum
suppresses growth of breast cancer cells through the inhibition of Akt/NF-kappaB 
signaling. Nutr Cancer. 2004;49(2):209-16. PubMed PMID: 15489214.


150: Sun J, He H, Xie BJ. Novel antioxidant peptides from fermented mushroom
Ganoderma lucidum. J Agric Food Chem. 2004 Oct 20;52(21):6646-52. PubMed PMID:
15479035.


151: Hong KJ, Dunn DM, Shen CL, Pence BC. Effects of Ganoderma lucidum on
apoptotic and anti-inflammatory function in HT-29 human colonic carcinoma cells. 
Phytother Res. 2004 Sep;18(9):768-70. PubMed PMID: 15478180.


152: Lu QY, Sartippour MR, Brooks MN, Zhang Q, Hardy M, Go VL, Li FP, Heber D.
Ganoderma lucidum spore extract inhibits endothelial and breast cancer cells in
vitro. Oncol Rep. 2004 Sep;12(3):659-62. PubMed PMID: 15289852.


153: Hsiao WL, Li YQ, Lee TL, Li N, You MM, Chang ST. Medicinal mushroom extracts
inhibit ras-induced cell transformation and the inhibitory effect requires the
presence of normal cells. Carcinogenesis. 2004 Jul;25(7):1177-83. PubMed PMID:
15205366.


154: Cao QZ, Lin ZB. Antitumor and anti-angiogenic activity of Ganoderma lucidum 
polysaccharides peptide. Acta Pharmacol Sin. 2004 Jun;25(6):833-8. PubMed PMID:
15169641.


155: Tomasi S, Lohézic-Le Dévéhat F, Sauleau P, Bézivin C, Boustie J. Cytotoxic
activity of methanol extracts from Basidiomycete mushrooms on murine cancer cell 
lines. Pharmazie. 2004 Apr;59(4):290-3. PubMed PMID: 15125575.


156: Jiang J, Slivova V, Valachovicova T, Harvey K, Sliva D. Ganoderma lucidum
inhibits proliferation and induces apoptosis in human prostate cancer cells PC-3.
Int J Oncol. 2004 May;24(5):1093-9. PubMed PMID: 15067330.


157: deVere White RW, Hackman RM, Soares SE, Beckett LA, Li Y, Sun B. Effects of 
a genistein-rich extract on PSA levels in men with a history of prostate cancer. 
Urology. 2004 Feb;63(2):259-63. PubMed PMID: 14972467.


158: Wachtel-Galor S, Tomlinson B, Benzie IF. Ganoderma lucidum ("Lingzhi"), a
Chinese medicinal mushroom: biomarker responses in a controlled human
supplementation study. Br J Nutr. 2004 Feb;91(2):263-9. PubMed PMID: 14756912.


159: Sliva D. Ganoderma lucidum (Reishi) in cancer treatment. Integr Cancer Ther.
2003 Dec;2(4):358-64. Review. PubMed PMID: 14713328.


160: Iwatsuki K, Akihisa T, Tokuda H, Ukiya M, Oshikubo M, Kimura Y, Asano T,
Nomura A, Nishino H. Lucidenic acids P and Q, methyl lucidenate P, and other
triterpenoids from the fungus Ganoderma lucidum and their inhibitory effects on
Epstein-Barr virus activation. J Nat Prod. 2003 Dec;66(12):1582-5. PubMed PMID:
14695801.


161: Sliva D, Sedlak M, Slivova V, Valachovicova T, Lloyd FP Jr, Ho NW. Biologic 
activity of spores and dried powder from Ganoderma lucidum for the inhibition of 
highly invasive human breast and prostate cancer cells. J Altern Complement Med. 
2003 Aug;9(4):491-7. PubMed PMID: 14499024.


162: Gao Y, Zhou S, Jiang W, Huang M, Dai X. Effects of ganopoly (a Ganoderma
lucidum polysaccharide extract) on the immune functions in advanced-stage cancer 
patients. Immunol Invest. 2003 Aug;32(3):201-15. PubMed PMID: 12916709.


163: Berovic M, Habijanic J, Zore I, Wraber B, Hodzar D, Boh B, Pohleven F.
Submerged cultivation of Ganoderma lucidum biomass and immunostimulatory effects 
of fungal polysaccharides. J Biotechnol. 2003 Jun 12;103(1):77-86. PubMed PMID:
12770506.


164: Ning J, Zhang W, Yi Y, Yang G, Wu Z, Yi J, Kong F. Synthesis of
beta-(1-->6)-branched beta-(1-->3) glucohexaose and its analogues containing an
alpha-(1-->3) linked bond with antitumor activity. Bioorg Med Chem. 2003 May
15;11(10):2193-203. PubMed PMID: 12713829.


165: Lin SB, Li CH, Lee SS, Kan LS. Triterpene-enriched extracts from Ganoderma
lucidum inhibit growth of hepatoma cells via suppressing protein kinase C,
activating mitogen-activated protein kinases and G2-phase cell cycle arrest. Life
Sci. 2003 Apr 11;72(21):2381-90. PubMed PMID: 12639703.


166: Lakshmi B, Ajith TA, Sheena N, Gunapalan N, Janardhanan KK.
Antiperoxidative, anti-inflammatory, and antimutagenic activities of ethanol
extract of the mycelium of Ganoderma lucidum occurring in South India. Teratog
Carcinog Mutagen. 2003;Suppl 1:85-97. PubMed PMID: 12616600.


167: Miura T, Yuan L, Sun B, Fujii H, Yoshida M, Wakame K, Kosuna K. Isoflavone
aglycon produced by culture of soybean extracts with basidiomycetes and its
anti-angiogenic activity. Biosci Biotechnol Biochem. 2002 Dec;66(12):2626-31.
PubMed PMID: 12596858.


168: Lu H, Kyo E, Uesaka T, Katoh O, Watanabe H. A water-soluble extract from
cultured medium of Ganoderma lucidum (Rei-shi) mycelia suppresses
azoxymethane-induction of colon cancers in male F344 rats. Oncol Rep. 2003
Mar-Apr;10(2):375-9. PubMed PMID: 12579275.


169: Li P, Zhang K. [Isolation, purification and bioactivities of exopoly
saccharides from fermented broth of Ganoderma lucidum]. Wei Sheng Wu Xue Bao.
2000 Apr;40(2):217-20. Chinese. PubMed PMID: 12548949.


170: Kimura Y, Taniguchi M, Baba K. Antitumor and antimetastatic effects on liver
of triterpenoid fractions of Ganoderma lucidum: mechanism of action and isolation
of an active substance. Anticancer Res. 2002 Nov-Dec;22(6A):3309-18. PubMed PMID:
12530080.


171: Sliva D, Labarrere C, Slivova V, Sedlak M, Lloyd FP Jr, Ho NW. Ganoderma
lucidum suppresses motility of highly invasive breast and prostate cancer cells. 
Biochem Biophys Res Commun. 2002 Nov 8;298(4):603-12. PubMed PMID: 12408995.


172: Hu H, Ahn NS, Yang X, Lee YS, Kang KS. Ganoderma lucidum extract induces
cell cycle arrest and apoptosis in MCF-7 human breast cancer cell. Int J Cancer. 
2002 Nov 20;102(3):250-3. PubMed PMID: 12397644.


173: Ghafar MA, Golliday E, Bingham J, Mansukhani MM, Anastasiadis AG, Katz AE.
Regression of prostate cancer following administration of Genistein Combined
Polysaccharide (GCP), a nutritional supplement: a case report. J Altern
Complement Med. 2002 Aug;8(4):493-7. PubMed PMID: 12230910.


174: Liu X, Yuan JP, Chung CK, Chen XJ. Antitumor activity of the
sporoderm-broken germinating spores of Ganoderma lucidum. Cancer Lett. 2002 Aug
28;182(2):155-61. PubMed PMID: 12048161.


175: Hsieh TC, Wu JM. Mechanism of action of herbal supplement PC-SPES:
elucidation of effects of individual herbs of PC-SPES on proliferation and
prostate specific gene expression in androgen-dependent LNCaP cells. Int J Oncol.
2002 Mar;20(3):583-8. PubMed PMID: 11836572.


176: Lu H, Kyo E, Uesaka T, Katoh O, Watanabe H. Prevention of development of
N,N'-dimethylhydrazine-induced colon tumors by a water-soluble extract from
cultured medium of Ganoderma lucidum (Rei-shi) mycelia in male ICR mice. Int J
Mol Med. 2002 Feb;9(2):113-7. PubMed PMID: 11786919.


177: Lu H, Uesaka T, Katoh O, Kyo E, Watanabe H. Prevention of the development of
preneoplastic lesions, aberrant crypt foci, by a water-soluble extract from
cultured medium of Ganoderma lucidum (Rei-shi) mycelia in male F344 rats. Oncol
Rep. 2001 Nov-Dec;8(6):1341-5. PubMed PMID: 11605062.


178: Lee JM, Kwon H, Jeong H, Lee JW, Lee SY, Baek SJ, Surh YJ. Inhibition of
lipid peroxidation and oxidative DNA damage by Ganoderma lucidum. Phytother Res. 
2001 May;15(3):245-9. PubMed PMID: 11351361.


179: Zhang L, Zhang M, Zhou Q, Chen J, Zeng F. Solution properties of antitumor
sulfated derivative of alpha-(1-->3)-D-glucan from Ganoderma lucidum. Biosci
Biotechnol Biochem. 2000 Oct;64(10):2172-8. PubMed PMID: 11129591.


180: Cheung WM, Hui WS, Chu PW, Chiu SW, Ip NY. Ganoderma extract activates MAP
kinases and induces the neuronal differentiation of rat pheochromocytoma PC12
cells. FEBS Lett. 2000 Dec 15;486(3):291-6. PubMed PMID: 11119721.


181: Ha TB, Gerhäuser C, Zhang WD, Ho-Chong-Line N, Fourasté I. New lanostanoids 
from Ganoderma lucidum that induce NAD(P)H:quinone oxidoreductase in cultured
hepalcic7 murine hepatoma cells. Planta Med. 2000 Oct;66(7):681-4. PubMed PMID:
11105584.


182: Porterfield H. UsToo PC-SPES surveys: review of studies and update of
previous survey results. Mol Urol. 2000 Fall;4(3):289-91;discussion 293. PubMed
PMID: 11062386.


183: de la Taille A, Hayek OR, Burchardt M, Burchardt T, Katz AE. Role of herbal 
compounds (PC-SPES) in hormone-refractory prostate cancer: two case reports. J
Altern Complement Med. 2000 Oct;6(5):449-51. PubMed PMID: 11059508.


184: Min BS, Gao JJ, Nakamura N, Hattori M. Triterpenes from the spores of
Ganoderma lucidum and their cytotoxicity against meth-A and LLC tumor cells. Chem
Pharm Bull (Tokyo). 2000 Jul;48(7):1026-33. PubMed PMID: 10923835.


185: Yun TK. Update from Asia. Asian studies on cancer chemoprevention. Ann N Y
Acad Sci. 1999;889:157-92. Review. PubMed PMID: 10668493.


186: Kim HS, Kacew S, Lee BM. In vitro chemopreventive effects of plant
polysaccharides (Aloe barbadensis miller, Lentinus edodes, Ganoderma lucidum and 
Coriolus versicolor). Carcinogenesis. 1999 Aug;20(8):1637-40. PubMed PMID:
10426820.


187: Wang SY, Hsu ML, Hsu HC, Tzeng CH, Lee SS, Shiao MS, Ho CK. The anti-tumor
effect of Ganoderma lucidum is mediated by cytokines released from activated
macrophages and T lymphocytes. Int J Cancer. 1997 Mar 17;70(6):699-705. PubMed
PMID: 9096652.


188: Yun TK, Kim SH, Lee YS. Trial of a new medium-term model using
benzo(a)pyrene induced lung tumor in newborn mice. Anticancer Res. 1995
May-Jun;15(3):839-45. PubMed PMID: 7645968.


189: Wang G, Zhang J, Mizuno T, Zhuang C, Ito H, Mayuzumi H, Okamoto H, Li J.
Antitumor active polysaccharides from the Chinese mushroom Songshan lingzhi, the 
fruiting body of Ganoderma tsugae. Biosci Biotechnol Biochem. 1993
Jun;57(6):894-900. PubMed PMID: 7763875.


190: Lieu CW, Lee SS, Wang SY. The effect of Ganoderma lucidum on induction of
differentiation in leukemic U937 cells. Anticancer Res. 1992
Jul-Aug;12(4):1211-5. PubMed PMID: 1503411.


191: Chen TW, Wong YK, Lee SS. [In vitro cytotoxicity of Ganoderma lucidum on
oral cancer cells]. Zhonghua Yi Xue Za Zhi (Taipei). 1991 Jul;48(1):54-8.
Chinese. PubMed PMID: 1653094.


192: Maruyama H, Yamazaki K, Murofushi S, Konda C, Ikekawa T. Antitumor activity 
of Sarcodon aspratus (Berk.) S. Ito and Ganoderma lucidum (Fr.) Karst. J
Pharmacobiodyn. 1989 Feb;12(2):118-23. PubMed PMID: 2746451.


193: Chen ZY, Yan RQ, Qin GZ, Qin LL. [Effect of six edible plants on the
development of AFB1-induced gamma-glutamyltranspeptidase-positive hepatocyte foci
in rats]. Zhonghua Zhong Liu Za Zhi. 1987 Mar;9(2):109-11. Chinese. PubMed PMID: 
2443327.